What are AMPs ?

Antimicrobial peptides (AMPs) are host defense molecules universal in the innate immune systems of both invertebrates and vertebrates. Because these ancient molecules remain potent after millions of years, they are regarded as important templates for developing a new generation of antimicrobials to combat antibiotic resistant superbugs and cancer.

The antimicrobial peptide database (APD, http://aps.unmc.edu/AP/) is an original database initially online in 2003. The APD2 (2009 version) has been regularly updated and further expanded into the APD3. This database currently focuses on natural antimicrobial peptides (AMPs) with defined sequence and activity. It includes a total of 2619 AMPs with 261 bacteriocins from bacteria, 4 AMPs from archaea, 7 from protists, 13 from fungi, 321 from plants and 1972 animal host defense peptides. The APD3 contains 2169 antibacterial, 172 antiviral, 105 anti-HIV, 959 antifungal, 80 antiparasitic and 185 anticancer peptides. Newly annotated are AMPs with antibiofilm, antimalarial, anti-protist, insecticidal, spermicidal, chemotactic, wound healing, antioxidant and protease inhibiting properties. Other searchable annotations, including target pathogens, molecule-binding partners, post-translational modifications and animal models are also described.

Genosphere Biotechnologies


Antibiofilm peptides

AP00095 : 6GIL , Name: Temporin B (temporin-1Tb; temporin-Tb; TB; Leu-rich; XXA, UCLL1c; frog, amphibians, animals; ZZP)

AP00150 : 1G89 , Name: Indolicidin (IR13; Tet083; XXA, Trp-rich, bovine cathelicidin, cattle, ruminant, mammals; animals; BBN; BBPP/BBII; Derivatives: CP-11, MBI-549, Omiganan pentahydrochloride (formerly MBI 226; MBI-226

AP00155 : 1FRY , Name: SMAP-29 (SMAP29, sheep myeloid AMP-29; SMAP-28, OaMAP28, ovine cathelicidin, sheep, ruminant, mammals, animals; BBomp; BBL; derivatives: Ovispirin, OV-1, OV-2, OV-3, novispirin, novici

AP00166 : 1Z64 , Name: Pleurocidin (NRC-4, NRC-04; WF2; XXA; fish, animals, UCLL1)

AP00195 : 1PG1 , Name: Protegrin 1 (Protegrin-1, PG-1, IB-200; UCSS1a; cathelicidin, pigs, mammals; animals; XXA, ZZHa, BBBm; Derivatives: Iseganan, protegrin IB 367 (IB-367); Clinical; BBL; JJsn; 2S=S)

AP00205 : 1WCO , Name: Nisin A (NisaplinTM, ChrisinTM, food additive E234; lantibiotic, type 1, class 1 bacteriocin, Gram-positive bacteria, prokaryotes; XXT5; XXW3; UCSS1b; ZZS; BBW; BBMm; JJsn; Variants: nisin AP)

AP00213 : P18252 , Name: Tachyplesin III (XXA, UCSS1a; 2S=S; Horseshoe Crab, arachnids, Chelicerata, arthropods, invertebrates, animals)

AP00283 : 1KJ6 , Name: Human beta defensin 3 (hBD-3, hBD3, or DEFB103, human defensin, 3S=S, UCSS1a; primates, mammals, animals; ZZHh; BBBh2o; BBW; JJsn)

AP00310 : 2K6O , Name: LL-37 [LL37; FALL-39; cathelicidin; UCLL1; human; chimpanzee; primates, mammals, animals; XXX; XXY; XXZ; BBBh2o, BBBm; BBMm, BBPP, BBN, BBL, BBrsg, JJsn; Derivatives: many)

AP00351 : P81835 , Name: Citropin 1.1 (UCLL1c; XXA, frog, amphibians, animals)

AP00366 : 2KET , Name: BMAP-27 (BMAP27, bovine myeloid antimicrobial peptide 27; bovine cathelicidin, cattle, ruminant, mammals, animals; ZZHs; ZZP; UCLL1; Derivatives: BMAP-18 and BMAP-15)

AP00367 : P54229 , Name: BMAP-28 (BMAP28, bovine myeloid antimicrobial peptide 28; bovine cathelicidin-5, cattle, ruminant, mammals, animals; BBMm;ZZP; UCLL1; Derivatives: mBMAP-28

AP00522 : Ref , Name: Agelaia-MP (Agelaia-MP-I; insects, arthropods, invertebrates, animals; XXA)

AP00548 : 2GDL , Name: Chicken CATH-2 (chicken cathelicidin 2; CMAP27, chicken myeloid antimicrobial peptide 27, Fowlicidin-2; chCATH-2; birds, animals; BBL; Derivatives: F2,5,12W)

AP00871 : Ref , Name: Temporin 1OLa (XXA, Temporin-1OLa, UCLL1c; frog, amphibians, animals. More AMPs?)

AP00897 : Ref , Name: NA-CATH (N. atra cathelicidin; snake, reptiles, animals)

Peptide mit speziellen Aufgaben.