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Genosphere Biotechnologies  -  Office Stuttgart

Avian IgY Antibodies

E-mail: info@genosphere-biotech.de   -   Telefon: 0711 9018185   -   Fax: 0711 9977707


From the Hens into the eggs ..


Since chickens are at least 100 million years removed from mammals, they tend to recognize any mammalian gene product as foreign and mount vigorous immune responses.


Antibodies derived from egg yolk.

Why Chicken affinity purified IgY?  -  Because, higher titres against

highly-conserved mammalian gene products!

Easier double immunostaining


Chicken IgYs can be used together with mouse and rabbit antibodies, without the danger of cross-reactivity. Secondary antibodies against chicken IgYs don’t cross-react with mammalian IgGs.


Higher detection signals


Chicken IgYs contain a larger glycosylation index, allowing more labeling with HRP and other antibody tags. This produces higher detection signals.


No "Fc domain" within the stem portion of a chicken IgY


This provides several advantages over rabbit IgGs:

Our Service

Protein analysis and peptide design ; Synthesis, purification & KLH conjugation of your peptide ; 4 immunisations, 70 days ; Egg collection, yolk isolation and total IgY purification ; Preparation of affinity column by covalent linkage of your peptide ; Affinity chromatography of your antibodies ; Quantitation ; ELISA, guaranteed titer >1:20 000

Delivery

IgY Antikörper werden aus Eidotter isoliert. Die Eier können kontinuierlich abgesammelt werden.

FAQ

IgY-Immunglobuline binden keine Fc-Rezeptoren auf Säugerzellen oder Fc-bindende Proteine aus Bakterien wie  Protein A, Protein G oder Protein L. Die Gefahr einer unspezifischen Hintergrundfärbung und falsch-positiven Ergebnissen, wie es in der Durchflusszytometrie (FACS) der Fall sein kann ist dadurch geringer. Aviäre IgY-Antikörper  reagieren nicht mit humanen Rheumafaktoren (RF), welche in Serumproben von Patienten mit rheumatoider Arthritis, aber auch in gesunden Menschen zu finden sind. IgY-Antikörper aktiveren zudem keine Komplementkaskade in Mammalia und sind daher für in vitro Anwendungen in Mammalia prinzipiell verwendbar.