References : Antibody development
Affinity purified polyclonal rabbit antibodies
Characterization of a Bioactive Peptide T14 in the Human and Rodent Substantia Nigra: Implications for Neurodegenerative Disease
by Susan Adele Greenfield 1,*,Giovanni Ferrati 1,Clive W. Coen 2ORCID,Auguste Vadisiute 3ORCID,Zoltan Molnár 3ORCID,Sara Garcia-Rates 1ORCID,Sally Frautschy 4 and Gregory M. Cole 4
https://doi.org/10.3390/ijms232113119
A novel peptide ‘T14’ reflects age and photo-aging in human skin
Sheila Rocha1 , Sara Garcia Ratés2 , Tumisang Moswete2 , Kristopher Kalleberg1 , Anna Villa1 , Jason P. Harcup1 , Susan A. Greenfield2
1 Unilever Research and Development, Trumbull, CT 06611, USA
2 Neuro-Bio Ltd, Culham Science Center, Abingdon, Oxfordshire OX14 3DB, UK
https://doi.org/10.18632/aging.204844
What´s up ?
Peptide stapling is revolutionising peptide chemistry by enhancing stability, solubility, and therapeutic potential. We highlight three recent examples that demonstrate its power in developing novel therapeutics for diseases like HIV, cancer, and neurodegenerative disorders.
"Bioinspired peptide stapling generates stable enzyme inhibitors"
Richard Morewood et al. (2022), Chem Commun (Camb).
The game-changing discovery of a bioinspired peptide staple that outperforms its linear analogue in enzyme inhibition, paving the way for innovative therapeutic applications.
"Squaric esters as peptide stapling reagents"
Adam X Wayment et al. (2024), Tetrahedron Lett.
A groundbreaking approach to selective peptide stapling reactions using squaric esters, enabling efficient and orthogonal conjugation of peptides on solid-phase resin.
"Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation"
Hidetomo Yokoo et al. (2021), Int J Mol Sci.
A breakthrough study demonstrating the enhanced stability and efficacy of peptide-based degraders through stapled structure, revolutionizing targeted protein degradation therapies.
*Genosphere Biotechnologies* offers expert solutions in peptide synthesis, antibody development, and gene expression to support your innovative research. Find more information at https://genosphere-biotech.com