zyklische Peptide
Directed cys-cys disulfide cyclization
Cyclic peptides have drawn considerable interest because of their improved chemical stability and significantly enhanced resistance to in situ enzymatic clearance (oral peptides) . The conformation is more rigid then the open-chain analog and may explain in part some of the observed improved biological activities. We routinely prepare cyclic peptides with head to tail ring closure. Directed cys-cys disulfide cyclization is also frequently achieved, and careful monitoring of the reaction ensures 100% cyclization.
#Thioether; #Lactam; #Lactone
internal glutamic acid cyclization
N-terminal amine to internal glutamic acid cyclization of a 27 aa peptide containing 21 hydrophobic residue (theoretical molar mass 2894) was prepared (100 mg) with purity level >95% and a sample analyzed by MALDI-TOF MS. MS shows loss of H2O (-18 amu) by condensation to yield desired product with molecular ion at m/z 2895.0.
Cyclische Peptide
Peptide mit 1 oder 2 Disulfid-Brücken.
z.B.
Peptide mit einer Cys-Cys Disulfid-Bücke und einer Länge von 10-12 Aminosäuren [ L-AA] *)
Menge: 2 mg
Reinheit: >95%
Preis: ab 399,05 € **)
Genosphere Biotechnologies Peptidsyntheseservice.
eMail: info@genosphere-biotech.de
*) andere Längen sind ebenfalls erhältlich.
**) zzgl. Versandkosten pro Lieferung.
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