zyklische Peptide / Makrozyklen

Directed cys-cys disulfide cyclization

Cyclic peptides have drawn considerable interest because of their improved chemical stability and significantly enhanced resistance to in situ enzymatic clearance (oral peptides) . The conformation is more rigid then the open-chain analog and may explain in part some of the observed improved biological activities. We routinely prepare cyclic peptides with head to tail ring closure. Directed cys-cys disulfide cyclization is also frequently achieved, and careful monitoring of the reaction ensures 100% cyclization.

#Thioether; #Lactam; #Lactone

Cyclische Peptide

**Peptide cyclisation -** Dimeric Peptides made by Genosphere Biotechnologies

Peptide mit 1 oder 2 Disulfid-Brücken.

z.B.

Peptide mit einer Cys-Cys Disulfid-Bücke und einer Länge von 10-12 Aminosäuren [ L-AA] *)

Menge: 2 mg
Reinheit: >95%

Preis: ab 499,05 € **)

Genosphere Biotechnologies Peptidsyntheseservice.
eMail: info@genosphere-biotech.de

*) andere Längen sind ebenfalls erhältlich.
**) zzgl. Versandkosten pro Lieferung.

internal glutamic acid cyclization

N-terminal amine to internal glutamic acid cyclization of a 27 aa peptide containing 21 hydrophobic residue (theoretical molar mass 2894) was prepared (100 mg) with purity level >95% and a sample analyzed by MALDI-TOF MS. MS shows loss of H2O (-18 amu) by condensation to yield desired product with molecular ion at m/z 2895.0.

N-terminal cyclic peptide modification

**Genosphere Biotechnologies Peptide Synthesis :** SATA = N-terminal S-acetyl-thioacetate

[sata] = N-terminal S-acetyl-thioacetate

Zugriffe heute: 3 - gesamt: 1437.

References : Peptide synthesis